A major component of green tea could prove the perfect elixir for severe sepsis an abnormal immune system response to a bacterial infection. In a new laboratory chew over. Haichao Wang. PhD of The Feinstein Institute for Medical Research and his colleagues have been studying the therapeutic powers of dozens of Chinese herbal compounds in reversing a fatal immune response that kills 225,000 Americans every year. They found that an ingredient in green tea rescued mice from lethal sepsis — and the findings could pave the way to clinical trials in patients. Dr. Wang had previously discovered a late mediator of sepsis called HMGB1 a substance expressed in the late stages of lethal sepsis. They wanted to figure out a way to block this substance which they felt would prevent the lethal sepsis affect from moving send. And it worked.
Scientists worldwide have been stumped by sepsis. Even with the most advanced medical techniques available half of those who develop sepsis die of the massive assault on the body. Several laboratories at the Feinstein Institute are working on sepsis — both on the basic biological aim and in patients. In the latest study. Dr. Wang’s group gave a substance in green tea called EGCG to mice in the throes of severe sepsis. The dose was equivalent to 10 cups in a human. Survival jumped from 53 percent in those who didn’t receive the green tea substance to 82 percent in those who did. “Clinically even if we could save five percent of patients that would be huge,” said Dr. Wang. “In this study we saved 25 percent more animals with the green tea.” He said that the green tea component. EGCG is readily available. There undergo been more than 100 papers focusing on this natural substance and its anti-cancer benefits. “This compound prevents HMGB1 from being released by immune cells and it also prevents it from activating immune cells to produce more cytokines,” he said. Cytokines are produced by immune cells and act as weapons to argue the body against invaders. “We are hoping to affect future arouse in clinical studies,” said Dr. Wang who worked on the study in collaboration with Wei Li. PhD. Andrew Sama. MD chairman of emergency medicine at North Shore University Hospital and other Feinstein investigators reports.
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